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The need for glutamine is particularly urgent in highly proliferating cells such as cancer cells and diseased blood vessel cells ( Dysfunction of Glutamine Metabolism in Pulmonary Hypertension Until now, metabolic reprogramming and mitochondrial dysfunction have been considered as the key events, leading to the excessive proliferation and anti-apoptosis of pulmonary vascular cells in the progress of PH ( It is well known that structural and functional alterations of pulmonary arterial smooth muscle cells (PASMC) and pulmonary artery endothelial cells (PAEC) lead to remodeling of the pulmonary artery wall and increase vascular resistance
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Ethanol consumption and serotonin-1A (5-HT1A) receptor function in heterozygous BDNF (+/−) mice
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