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Chronic NF-ĸB stimulation promotes cellular infiltration and mucosal inflammation by increasing the transcription of proinflammatory cytokines (e.g., IL-6, IL-8, IL-16, and TNF-α) and by degrading the intestinal barrier through increased apoptosis of intestinal epithelial cells ( Figure 3 ) (75), up-regulation of metalloproteinases which digest mucosal cells, and the release of ROS metabolites that activate NF-ĸB to further impair barrier stability (76)
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La vitamine C est souvent utilisée dans les soins cosmétiques pour aider à améliorer l’éclat naturel de la peau et atténuer l’apparence des taches pigmentaires
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