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It inhibits succinate dehydrogenase (SDH)-driven succinate oxidation(345) which is a powerful proinflammatory mechanism(346) and also regulates the activity of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2), which controls the expression of antioxidant proteins such as heme oxygenase, critical for cellular defense against oxidative stress(347)
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Common analytical methods include HPLC, mass spectrometry, molecular weight analysis, and analytical assay verification
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