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4.4.2 PTGS2 and COX-2 serve as both biomarkers and mediators of ferroptosis In addition to its pro-inflammatory characteristics, COX-2 is recognized as a significant downstream indicator of ferroptosis, especially concerning neuronal injury (Mohan et al., 2024)
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Interestingly, in preclinical models, insulin-like growth factor-1 (IGF-1) significantly protects against CSD by mitigating oxidative stress and microglial neuroinflammation [108,109,110,111]
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