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The GH/IGF-1 axis in ageing and longevity | Nature Reviews Endocrinology
Due to the fact that there is no simple way to assess whether the replacement dose of glucocorticoid is correct, clinical evaluation is necessary to identify signs and symptoms of over-or under-replacement
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Following their systemic spread via the circulation, the opposite is necessary for the colonization of distal organs, which depends on a (partial) reversion into less motile cells with regained matrix adhesion (Gunasinghe et al., 2012
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