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Chronic pulmonary inflammation further exacerbates iron dyshomeostasis, resulting in increased iron accumulation in alveolar epithelial cells and macrophages, thereby forming a vicious cycle ( − , reduces intracellular GSH levels, and inhibits the activity of GPX4, collectively weakening the cell’s antioxidant defense (Wang et al., 2022b)
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In addition, HFD rats demonstrated significant diet-induced changes particularly in the pancreas
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