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225 After systematic SAR studies, [ trans -diamminechloroplatinum(II)][µ- trans -diamminedihexanediamineplatinum(II)] nitrate (BBR3464) was selected for preclinical development
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Furthermore, sirolimus exerts its effects by inhibiting the synthesis of cell cycle–related proteins, impeding lymphocyte G1-to-S phase transition, and promoting the activation of apoptosis-related pathways
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