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It is structurally distinct from IGF-1 LR3 and acts through what some researchers describe as an MGF-specific receptor pathway, although the precise receptor identification remains debated in the published literature
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demonstrated that increased IGF-1 levels are associated with trastuzumab resistance [118], recent focus has turned into clarifying the cross-talk between the IGF-1 system and the Epidermal Growth Factor Receptors (EGFR) family
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