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Using a transgenic eGFP knockin mouse under control of the GHSR promoter [63], Zigman and colleagues showed that GHSR-eGFP expression was distributed throughout several additional, higher-order limbic brain regions that lack significant GHSR mRNA expression, including the prefrontal cortex, insular cortex, amygdala, and hippocampus

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5.2 ART-induced mtDNA mutations and their clinical implications Beyond acute depletion, long-term ART exposure is associated with the accumulation of mtDNA mutations, which have profound implications for aging and age-related diseases