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We rather anticipated anxiolytic effects after chronic inhibition of system x c − using SAS, as seen in naive mice lacking functional system x c − ( −/− mice did not show a convincing anxiolytic phenotype when compared to saline-injected xCT +/+ mice, and even a borderline-significant anxiogenic phenotype in the EPM (Mann-Whitney test: cumulative duration in the center of the OF: w2: p = 0.6047, w3: p = 0.04679, w4: p = 0.2895, w5: p = 0.9725