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Gln metabolism directly or indirectly influences epigenetic processes, such as DNA methylation and histone modification, through mechanisms of βsubstrate supplyβ and βcofactor regulation
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GSH, in particular, would act as a neuroprotective agent binding Cis-DDP and other platinum compounds such as oxaliplatin, preventing the first step of neuronal damage that is platinum accumulation in peripheral nerves [105,106]
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