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Downstream, dermal fibroblast studies report increased synthesis of collagen types I and III, glycosaminoglycans, and the proteoglycan decorin, alongside modulation of matrix metalloproteinases and their tissue inhibitors — that is, GHK-Cu is described as tuning both the building and the breakdown side of matrix turnover rather than simply adding collagen
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[DOI] [PubMed] [Google Scholar] Carver-Moore K, Broxmeyer HE, Luoh SM, Cooper S, Peng J, Burstein SA, Moore MW and de Sauvage FJ
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