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Several targeted agents for the treatment of advanced carcinoma are now approved and in clinical use: the anti-VEGF ligand inhibitors (bevacizumab and aflibercept), the anti-angiogenic small-molecule multi-target tyrosine kinase inhibitors (MTKIs) (sunitinib, sorafenib, pazopanib, ponatinib, axitinib, cabozantinib, vandetanib) that target the VEGF-receptor VEGFR-2, the platelet-derived growth factor (PDGF)_ receptor, rat sarcoma (RAS), stem-cell factor receptor c-KIT and the mammalian target of rapamycin (mTOR) inhibitors, temsirolimus and everolimus [57, 58]