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When antibiotics, particularly sulphur drugs are used for extended periods, the normal synthesis of folic acid in the gut will be reduced and the requirement for folic acid are increased
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The deficiency of this chemokine resulted in the reduced recruitment of microglia and astrocytes as reflected by delayed demyelination and an attenuated TNF-α secretion after 3.5 weeks of cuprizone ingestion (McMahon et al., 2001)
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