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melanotan ii autism study MARK2 variants cause spectrum disorder via the downregulation of WNT/β-catenin signaling pathway: The American Journal of Human Genetics Luminous Skin
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22 Insulin signaling pathways Physiologically, insulin binds to the extracellular α subunit of insulin receptor, a receptor tyrosine kinase which recruits and phosphorates insulin receptor substrate (IRS)-1, thus activating phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling and diverse downstream pathways to maintain the glucose homeostasis
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