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22 Insulin signaling pathways Physiologically, insulin binds to the extracellular α subunit of insulin receptor, a receptor tyrosine kinase which recruits and phosphorates insulin receptor substrate (IRS)-1, thus activating phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling and diverse downstream pathways to maintain the glucose homeostasis
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japonica could reduce liver oxidative harm in diabetic rats induced by streptozotocin (STZ)
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