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This abrupt hormonal withdrawal triggers endometrial shedding (menstruation) and relieves negative feedback at the HPO axis, allowing FSH levels to rise and initiate recruitment of a new follicular cohort, thereby completing the cycle [23]
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To facilitate the use of recombinant enzymes to test the substrate specificity in vitro , protein arginine N-methyltransferase (PRMT) was cloned in frame into pGEX vectors using standard molecular biology techniques
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