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It also explains why oral protocols are sometimes dosed away from large meals or split across the day — to manage transit and local contact time rather than to chase a blood-level peak
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This interaction is buttressed by f-Phe496 and f-Val500, which have previously been shown essential for SiRFP-SiRHP binding – the F496D alteration abrogates SiRHP binding and the V500D alteration reduces SiRHP binding 300-fold but both are able to reduce a cytochrome c substrate when supplied with NADPH 15
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