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The choice of suitable linker chemistry is often based on intuition, but the significant pH difference between endosomes and the extracellular space (ΔpH ≈ 2) makes it easier to achieve selective release

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These findings suggest that the delivery of drugs using dendrimers could be a potential strategy for targeting glia and attenuating oxidative stress and immune dysregulation in patients with Rett syndrome, a rare progressive developmental disorder with no effective cure [153]