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If the DNA damage is too severe or there is a defect in the DNA repair pathway, DNA repair will ultimately fail 5-7
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6 Coincidentally, downregulated Sirtuin 3 (Sirt3)-mediated hyperacetylation of PDHA1 promotes the lactylation of mitochondrial fission 1 protein (Fis1) at K20 by increasing lactate overproduction in renal tubular epithelial cells, resulting in excessive mitochondrial injury
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