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Further assessment of GPX and glutathione reductase (GRed) activities revealed that, along with changes in GSH and GSSG, the total GPX activity and mitochondrial GPX activity were significantly elevated in mutant cells compared to the control group
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Given that Cu has also been shown to destabilize Fe–S proteins in bacteria and yeast, it is reasonable to speculate that a Cu-containing complex might be developed to trigger cuproptosis in bacteria as an antimicrobial agent
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