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Glutathione transferases (GST) conjugate the tripeptide via its thiol group to endogenous and exogenous electrophilic compounds (Hayes et al., 2005

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Alternative repletion strategies have focused on oral administration of GSH precursors (e.g., cysteine and glycine supplementation 9 ), and intravenous administration of GSH, 10 which although promising, is invasive and inconvenient, and therefore unlikely to be a practical solution