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During HBOT, initial hyperoxic circumstances cause the creation of reactive oxygen species (ROS), which leads to the overexpression of antioxidant genes such as superoxide dismutase (SOD), glutathione reductase (GRx), and glutathione peroxidase (GPx) (Iorio, 2006
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It acts as a physiological ligand for Fe 2 + , promoting assembly of iron-sulfur (Fe-S) clusters and biosynthesis of Fe-S proteins, which participate in essential biological functions including electron transfer, the Krebs cycle, maintenance of genome integrity, enzymatic catalysis, and iron homeostasis 15
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