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She explains that menopausal women often show “an increase of antioxidant capacity … as well as lower glutathione levels along with high levels of oxidative damage.” According to Tennant, this rise in antioxidant capacity may be compensatory—a protective response as the body ramps up defenses to counteract mounting oxidative stress.“Since glutathione levels decrease while oxidative stress increases, it’s reasonable to consider supplementing with glutathione or NAC, alongside lifestyle interventions like exercise, diet, sleep, stress management, and possibly hormone replacement therapy,” Tennant says