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Although rare, risks and complications that apply to lumbar ESI injections include: While it’s very rare, receiving a lumbar epidural steroid injection can lead to some long-term complications, including: Many people experience temporary pain relief from lumbar epidural steroid injections, and some people even experience longer-term relief lasting up to 12 months
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The FDA's 2024 review found no published human pharmacokinetic study that formally characterized the subcutaneous route, so these amounts are anecdotal rather than an approved clinical protocol
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