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Studies in mice (Alfonso-Loeches et al., As indicated earlier, ASA acutely acetylates Cox-1 and chronically also Cox-2, leading to the generation of the powerful anti-inflammatory 15- R epi-Lipoxin A4 (or ASA triggered lipoxin ATL), a metabolite of arachidonic acid (Romano et al., 2015
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In the absence of clear objective or subjective signs of improvement with standard second-line treatments, one might consider exploring innovative therapies like tocilizumab or bortezomib, despite the limited evidence of their efficacy [5]
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