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In the studies that proofed tumor growth inhibition by a KD fed ad libitum, there was a significant increase in KB levels, but not necessarily decreases in blood glucose levels or body weight

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A plausible diagnosis of SS can therefore only be made when there is a high Bayesian prior probability (high index of clinical suspicion) in the setting of starting, increasing (or overdose) of a relevant serotonergic drug, or shortly after a second serotonergic drug is added