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These analyses showed that TRP levels negatively correlated with the actual gravity of depressive and manic symptoms, evaluated by means of the HAM-D and YMRS respectively, with some domains of the lifetime dimensional mood spectrum symptomatology assessed by MOODS-SR (particularly Energy Depressive , Rhythmicity and Total Depressive score ) and with the impairment in the several areas of subject’s functioning measured by means of the WSAS scale
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Intrinsic skin aging is linked to reduced cell replication capacity and the weakening of the extracellular matrix
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