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In other words, ~1% of patients below the line who are untreated will develop hepatotoxicity (defined as transaminitis) Acute APAP Ingestion Definition: Entire ingestion occurring within 8-hour period Measure APAP concentration at 4 hours from time of ingestion and plot on Rumack-Matthew Nomogram If [APAP] is above the 150-line, treat with NAC as below

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These mutations result in catalytic deficiency of PBGD, the third enzyme in haem biosynthesis [4], with a residual enzymatic activity approximately half the normal levels