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These three nAb epitopes are largely located on the opposite side of the RBM compared with the epitopes of class I nAbs
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Bevacizumab (Avastin) is a humanised IgG 1 monoclonal antibody that binds all VEGF-A isoforms with 58 pM ( K d ) affinity to VEGF-A 165 and blocks VEGFR2 signalling [113,114]
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