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Crucially, the sequence modifications that produce this activity also eliminate the binding affinity for the GHR Ig-like domain, which is the structural feature responsible for IGF-1 secretion and hyperglycemic effects in full-length GH
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Huttinger C, Hirschberger J, Jahnke A, Kostlin R, Brill T, Plank C, et al (2008): Neoadjuvant gene delivery of feline granulocyte-macrophage colony-stimulating factor using magnetofection for the treatment of feline fibrosarcomas: a phase I trial
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