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Profibrotic signaling is reinforced by Polycomb Repressive Complex 2/Enhancer of Zeste Homolog (PRC2/EZH2)- and G9a-driven methylation (Histone H3 Lysine 27 Trimethylation/Histone H3 Lysine 9 Di/Trimethylation (H3K27me3/H3K9me2/3)) and by p300-dependent acetylation, which together promote TGF-β and STAT3 programs in fibrotic organs
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