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23 Furthermore, they reported that intravenous administration of these EVs (100 μg/mouse, three times weekly for 8 weeks) to high-fat diet-fed ApoE−/− mice resulted in approximately 35% reduction in aortic plaque area, with PKH67-labeled EVs accumulating in atherosclerotic lesions within 24 hours and co-localizing with CD68+ macrophages—suggesting preferential delivery to foam cell-rich regions
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Aspirin ameliorates atherosclerotic immuno-inflammation through regulating the Treg/Th17 axis and CD39-CD73 adenosine signaling via remodeling the gut microbiota in ApoE(-/-) mice
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