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CoAs typically include identity confirmation using validated analytical techniques such as mass spectrometry or equivalent methods, along with purity or composition assessment via chromatography-based analysis (e.g., HPLC)
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For example, in the fed state, the nuclear-cytoplasmic acetyl-CoA generated from glycolysis and the mitochondrial export of citrate can alter histone acetylation in addition to driving lipid synthesis (104,108)
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