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Residue-binding free energy analysis pointed out the significance of T107 and L113 in BDNF, along with L444, F463, and F487 in TLR4 (Supplementary Table S2, S3)
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Since the METIV-HCC trial selected patients with high c-Met levels, this does not necessarily mean that tivantinib has no role in targeted treatment in HCC patients
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