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Similarly, melanoma-secreted exosomes contain miR-498 and miR-3187-3p which are internalized by CD8 + T cells, where miR-498 interacts with the 3βUTR of Tnf (encoding tumor necrosis factor alpha, TNF-Ξ±) mRNA to reduce TNF-Ξ± secretion by T cells and miR-3187-3p binds with 3βUTR of protein tyrosine phosphatase receptor type C (Ptprc) mRNA, impairing CD45 production and T cell receptor (TCR) signaling in CD8 + T cells [136]
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The lipopeptide antibiotic Friulimicin B inhibits cell wall biosynthesis through complex formation with bactoprenol phosphate
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