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Moreover, astaxanthin caused an M2-dominant shift in macrophages/Kupffer cells and a subsequent reduction in CD4 + and CD8 + T cell recruitment in the liver, which contributed to improved insulin resistance and hepatic inflammation

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When rupture occurs, the plaque exposes underlying pro-thrombotic substances, leading to platelet aggregation and thrombus formation, which are key processes in the pathogenesis of acute coronary syndromes, such as myocardial infarction and unstable angina