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These four subtypes also differ in prognosis and therapeutic responses ( Breast cancer can be diagnosed through both conventional and contemporary methods such as mammography, magnetic resonance imaging (MRI), tissue biopsy, immunohistochemistry (IHC), and gene expression by next-generation sequencing (NGS) technology ( Recent advancements in bioinformatics methods, artificial intelligence (AI) and machine learning (ML) have transformed the area of breast cancer studies ( This review provides a comprehensive picture and insight into the breast cancer research with emphasis on several risk factors, traditional and emerging trends in pathogenesis, diagnosis, subtype classification, and tailored treatment ( Figure 1 )

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As a result of eIF-2α phosphorylation translation of the transcription factor, activating transcription factor 4 (ATF4) is enhanced

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