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Recommended medications for subcutaneous EPKINLY 1 RECOMMENDED PRE- AND POST-ADMINISTRATION MEDICATIONS prior to EPKINLY administration CYCLE 1 All patients, each weekly administration Dexamethasone † or Prednisolone or equivalent 15 mg oral or IV (dexamethasone), 100 mg oral or IV (prednisolone), or equivalent And for 3 consecutive days following each weekly administration of EPKINLY in cycle 1 Diphenhydramine or equivalent 50 mg oral or IV, or equivalent Acetaminophen 650 mg to 1000 mg oral CYCLE 2+ Patients who experienced grade 2 or 3 ‡ CRS with previous dose until EPKINLY is given without subsequent CRS of grade 2 or higher Dexamethasone † or Prednisolone or equivalent 15 mg oral or IV (dexamethasone), 100 mg oral or IV (prednisolone), or equivalent Administered prior to next administration of EPKINLY and for 3 consecutive days following the next administration of EPKINLY Diphenhydramine or equivalent N/A † Dexamethasone is the preferred corticosteroid when available

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