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So, we recommend using SL vitamin B12 rather than oral and IM, especially in patients who do not tolerate IM injection and patients who need prolonged vitamin B12 supplementation, such as patients with long-term metformin use and patients with pernicious anemia or with gastro-duodenal resection [51–54]

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In both vector-expressing and xCT-expressing cells, CBS deletion compromised cell proliferation specifically when extracellular cysteine was limited, but not when the medium contained a high level of cysteine (Figure S5C and S5D)