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Food and Drug Administration (FDA) approved an expanded indication for semaglutide to reduce the risk of progression of kidney disease, end-stage kidney disease, and cardiovascular death in adults with T2DM and CKD.7 In the 2025 Standards of Care issued by the American Diabetes Association, the use of GLP-1 RAs and/or sodium-glucose cotransporter-2 inhibitors is strongly recommended for individuals with T2DM who are at high cardiovascular or kidney risk, irrespective of baseline HbA1c or metformin therapy.8 Taken together, these developments elevate semaglutide from a glucose-lowering agent to a disease-modifying therapy with benefits across multiple organ systems.9 Parallel to GLP-1–based therapies, amylin biology has re-emerged as a therapeutic target