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Epigenetics refers to heritable changes in gene activity that do not involve alterations to the DNA sequence but are instead mediated by DNA methylation, histone modifications, nucleosome positioning, higher-order chromatin architecture, RNA-based mechanisms and epigenetic factors (Fig
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Since the complex between Siah and GAPDH stabilizes this E3 ubiquitin ligase, turnover of Siah’s nuclear target proteins is increased, which in turn leads to cell death
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