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The site-specific PEGylated interleukin-4 (IL-4) has an approximately 6-fold improvement in terminal half-life from 0.76 to 4.7 h as compared with unmodified IL-4 and above 3-fold improvement in the total drug exposure across time
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By promoting this GLT-1 upregulation and facilitating the clearance of excess synaptic glutamate, NAC contributes to relapse prevention in substance use disorder [76]
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