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It seems evident that the difficult nosographic placement (a), the often numerically insufficient population selection to arrive at the representativeness necessary to be able to consider the results of the studies reasonably functional to the research objectives (b), the heterogeneity of symptoms among them not coherently connected according to a logical continuum (c), the absence of a precise and shared independent diagnostic procedure and not according to the logic of exclusion (d), the absence of one or more specific marker (e.g