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Although there are still many limitations, these findings provide new insights for future studies on depression

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A growing consensus suggests that HIC and NHIC may represent two distinct disease entities or different stages within a disease spectrum, with partially distinct etiological mechanisms and treatment responses ( Historically, diagnosis relied on cystoscopic identification of Hunner’s ulcers or mucosal tears/bleeding after hydrodistension (80–100 cmH 2 O for 1–2 minutes)