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Epithalon Research Protocols & Administration Dosing in Published Research Research investigations have employed varied Epithalon doses depending on species, study objectives, and administration protocols: Rodent studies: 1-100 mcg/kg body weight (most common: 10 mcg/kg) Primate studies: 10-50 mcg/kg used in neuroendocrine research Cell culture studies: 0.001-5 mcg/mL concentrations effective Human studies: 1-10 mg total dose in limited clinical investigations Important: These are experimental doses used in animal studies and cannot be extrapolated to other species due to significant differences in metabolism, receptor density, pharmacokinetics, and peptide degradation rates

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PANS: Pediatric Acute-onset Neuropsychiatric Syndrome Neurobiologic, Immunologic, and Rheumatologic Markers in Youth With PANS ( Trial number: NCT02889016 Overview: This study investigates brain, immune system, and joint-related markers in children with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS), a condition with sudden onset of obsessive-compulsive disorder or eating problems and other psychiatric symptoms