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This clinical review found that oral vitamin B12 absorption is capped by a saturable intrinsic-factor pathway (roughly 50–60% of a small dose, limited to about 1.5–2.5 mcg per meal) plus a small passive-diffusion component (about 1%), a ceiling that intramuscular injection bypasses by delivering B12 directly into the bloodstream.
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The first phase project was completed in 2005, and got the GMP certification successfully
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