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However, the main issue that limits the clinical application of these barrier disruption techniques is the relatively uncontrolled disruption of BBB tight junction complex integrity could result in xenobiotic, toxin and microbe entry from circulation into the brain via paracellular passive diffusion 87
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In human beings, the maintenance of reduced body weight is achieved via coordination of metabolic, neuroendocrine, and autonomic responses that normally favor weight regain following a loss [40]
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