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With the exception of the kokumi receptor ECD, high-resolution crystal structures for any taste receptor would be a major step toward designing novel and potent surrogate taste receptor ligands and selective antagonists
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118 In recent years, accumulating evidence has highlighted the intricate interplay between bioenergetic deficits and redox imbalance in the pathophysiology of both SZ and aging, as alterations in energy metabolism, mitochondrial function, oxidative metabolism, and energy production pathways in the brain have been implicated in both conditions
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