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sildenafil) Success rate of ~65% Pharmacokinetics: Can be injected directly into the cavernosa, used as a topical cream, or placed in the urethra as a minisuppository, from which it diffuses into the cavernosal tissue Side Effects: penile pain (29-49% of users) - most likely due to direct pain-mediating effects of PGE urethral bleeding (5%) hypotension within 1 hour of use (3.3%) Note: Phentolamine can be used by injection as well (as another alternative therapy) References: Smyth EM, FitzGerald GA (2015): The Eicosanoids: Prostaglandins, Thromboxanes, Leukotrienes, & Related Compounds (Chapter 18)

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مقاس:60 عد

10.1007/s11684-020-0804-7 [DOI] [PubMed] [Google Scholar] Zhou Y., Yang J., Chen C., Li Z., Chen Y., Zhang X., et al

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